Title : The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.

Pub. Date : 2016 Nov 16

PMID : 27849062






2 Functional Relationships(s)
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1 Whether its phosphorylated form, FTY720-P, also enhances PP2A activity independently of the sphingosine 1-phosphate (S1P) pathway was unknown. FTY 720P protein phosphatase 2 phosphatase activator Homo sapiens
2 Herein, we show that FTY720-P enhances TNF-induced PP2A phosphatase activity and significantly represses TNF-induced interleukin 6 (IL-6) and IL-8 mRNA expression and protein secretion from A549 lung epithelial cells. FTY 720P protein phosphatase 2 phosphatase activator Homo sapiens