Title : Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis.

Pub. Date : 2017 Jan

PMID : 27848074






3 Functional Relationships(s)
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1 Induction of autophagy by salidroside through the AMPK-mTOR pathway protects vascular endothelial cells from oxidative stress-induced apoptosis. rhodioloside protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
2 Salidroside upregulated AMPK phosphorylation but downregulated mTOR phosphorylation under oxidative stress; however, administration of compound C, an AMPK inhibitor, abrogated AMPK phosphorylation and increased mTOR phosphorylation and apoptosis compared with salidroside alone. rhodioloside protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens
3 These results suggest that autophagy is a protective mechanism in HUVECs under oxidative stress and that salidroside might promote autophagy through activation of the AMPK pathway and downregulation of mTOR pathway. rhodioloside protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens