Pub. Date : 2017 Jan
PMID : 27840968
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib inhibited the expression of phospho-ERK and -4EBP1 in 769-P cells; sunitinib, phospho-ERK and -4EBP1 in 786-O and 769-P cells; and everolimus, phospho-p70 in 786-O and 769-P cells. | Sorafenib | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Knockdown of ERK reduced sensitivity to sorafenib in both cell lines, knockdown of ERK and 4EBP1 reduced sensitivity to sunitinib in 769-P cells, and knockdown of 4EBP1 and p70 reduced sensitivity to everolimus in 786-O cells. | Sorafenib | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | High expression of phospho-ERK, -4EBP1 and -p70 correlated with better progression-free survival in patients treated with sorafenib, sunitinib and everolimus, respectively. | Sorafenib | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Our results indicate that phospho-ERK, -4EBP1 and/or -ERK, and phospho-p70 can be used as biomarkers for the therapeutic efficacy of sorafenib, sunitinib and everolimus, respectively. | Sorafenib | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Our results indicate that phospho-ERK, -4EBP1 and/or -ERK, and phospho-p70 can be used as biomarkers for the therapeutic efficacy of sorafenib, sunitinib and everolimus, respectively. | Sorafenib | mitogen-activated protein kinase 1 | Homo sapiens |