Pub. Date : 1989 Feb
PMID : 2783675
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modification of tissue-factor mRNA and protein response to thrombin and interleukin 1 by high glucose in cultured human endothelial cells. | Glucose | interleukin 1 alpha | Homo sapiens |
| 2 | In contrast, the tissue-factor response to interleukin 1, a modulator of endothelial function in the context of host defense, was decreased in cells cultured in high glucose (P = .04). | Glucose | interleukin 1 alpha | Homo sapiens |
| 3 | The reciprocal effects of high glucose on the tissue-factor response to thrombin and interleukin 1 points to different pathways of tissue-factor stimulation by the two agents and suggests functional consequences pertinent to the increased thrombin activity and compromised host-defense mechanisms observed in diabetes. | Glucose | interleukin 1 alpha | Homo sapiens |