Title : Inhibition of EMMPRIN and MMP-9 Expression by Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor in PMA-Induced Macrophages.

Pub. Date : 2016

PMID : 27832636






3 Functional Relationships(s)
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1 RESULTS: We showed that EGCG (10-50micromol/L) significantly inhibited the expression of EMMPRIN and MMP-9 and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and c-Jun N-terminal kinase (JNK) in PMA-induced macrophages. epigallocatechin gallate mitogen-activated protein kinase 8 Homo sapiens
2 RESULTS: We showed that EGCG (10-50micromol/L) significantly inhibited the expression of EMMPRIN and MMP-9 and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and c-Jun N-terminal kinase (JNK) in PMA-induced macrophages. epigallocatechin gallate mitogen-activated protein kinase 8 Homo sapiens
3 Anti-67LR antibody treatment led to abrogation of the inhibitory action of EGCG on the expression of EMMPRIN and MMP-9 and activation of ERK1/2, p38, and JNK. epigallocatechin gallate mitogen-activated protein kinase 8 Homo sapiens