Pub. Date : 2016 Oct
PMID : 27831630
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Data collected during the last 10 years reported a dose-duration dependent increasing of cardiovascular risk associated with the use of diclofenac, supporting the evidence of a close association with the degree of COX-2 inhibition achieved in vivo. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Today, new low-dosage diclofenac formulations are available, allowing to reduce the systemic exposure, the degree of COX-2 inhibition and possibly the risk of occurrence of cardiovascular events. | Diclofenac | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |