Pub. Date : 2017 May
PMID : 27830268
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Sodium butyrate (NaBt) strongly potentiated the BaP-induced expression of CYP1A1 in human colon carcinoma HCT116 cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Up-regulation of CYP1A1 expression/activity corresponded with an enhanced metabolism of BaP and formation of covalent DNA adducts. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | This in vitro study suggests that butyrate, through modulation of histone acetylation, may potentiate induction of CYP1A1 expression, which might in turn alter the metabolism of BaP within colon epithelial cells. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |