Pub. Date : 2016
PMID : 27826185
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor). | Celecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor). | Celecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | These selective COX2 inhibitors were docked into the active site of COX2, and showed the same orientation and binding mode to that of celecoxib (selective COX2 inhibitor). | Celecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Docking studies also showed that the SO2NH2 of 5u and 5s is inserted deep inside the selective pocket of the COX2-active site and formed a hydrogen-bond interaction with His90, Arg513, Phe518, Ser353, Gln192, and Ile517, which was further validated by superimposed docked pose with celecoxib. | Celecoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |