Title : Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities.

Pub. Date : 2017 Jan

PMID : 27821437






1 Functional Relationships(s)
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1 CAP and PIP were significantly more potent inhibitors of CYP1A2 (IC50 2.14 +- 0.22 microM and 14.19 +- 4.15 microM, respectively) than CUR (IC50 > 100 microM), while all three SCs exhibited weak activity toward CYP2D6 (IC50 95.42 +- 12.09 microM for CUR, 99.99 +- 5.88 microM for CAP, and 110.40 +- 3.23 microM for PIP). Capsaicin cytochrome P450 family 1 subfamily A member 2 Homo sapiens