Title : Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice.

Pub. Date : 2017

PMID : 27820939






2 Functional Relationships(s)
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Protein Name
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1 Activation of PAR-1 enhanced poly I:C induction of IFNbeta and CXCL10 expression in the murine macrophage cell line RAW264.7, bone-marrow derived mouse macrophages (BMM) and mouse splenocytes. Poly I-C chemokine (C-X-C motif) ligand 10 Mus musculus
2 We found that poly I:C treated PAR-1-/- mice and WT mice given the thrombin inhibitor dabigatran etexilate exhibited significantly less IFNbeta and CXCL10 expression in the spleen and plasma than WT mice. Poly I-C chemokine (C-X-C motif) ligand 10 Mus musculus