Title : The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1.

Pub. Date : 2016

PMID : 27820923






4 Functional Relationships(s)
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1 Exposure to 0.1, 1 and 10 ppm NO2 or synthetic air as a control was performed for 1 h. Subsequently, the cells were exposed to Der p 1 for 24 h. The release of interleukin (IL)-6 and IL-8 was measured by ELISA, and the production of IL-6 mRNA and IL-8 mRNA was measured by RT-PCR. Nitrogen Dioxide interleukin 6 Homo sapiens
2 NO2 exposure resulted in a concentration-dependent release of IL-6, but not IL-8 release. Nitrogen Dioxide interleukin 6 Homo sapiens
3 The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release. Nitrogen Dioxide interleukin 6 Homo sapiens
4 The coexposure of 0.1 ppm NO2 and Der p 1, or 1 ppm NO2 and Der p 1 significantly increased both IL-6 and IL-8 release. Nitrogen Dioxide interleukin 6 Homo sapiens