Title : Interleukin-1β induces sleep independent of prostaglandin D2 in rats and mice.

Pub. Date : 2017 Jan 6

PMID : 27815021






2 Functional Relationships(s)
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1 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide interleukin 1 beta Rattus norvegicus
2 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide interleukin 1 beta Rattus norvegicus