Title : Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.

Pub. Date : 2017 Jan

PMID : 27803021






1 Functional Relationships(s)
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1 Fedratinib inhibited thiamine uptake into Caco-2 cells (IC50 = 0.940 microM) and THTR-2 (IC50 = 1.36 microM) and, to a lesser extent, THTR-1 (IC50 = 7.10 microM) overexpressing cells. Fedratinib solute carrier family 19 member 3 Homo sapiens