Title : Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters.

Pub. Date : 2017 Jan

PMID : 27803021






1 Functional Relationships(s)
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1 Further studies with drugs containing a 2,4-diaminopyrimidine resulted in the discovery that the antibiotic trimethoprim also potently inhibits thiamine uptake mediated by THTR-1 (IC50 = 6.84 microM) and THTR-2 (IC50 = 5.56 microM). 2,4-diaminopyrimidine solute carrier family 19 member 3 Homo sapiens