Pub. Date : 2016
PMID : 27802433
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. | Reactive Oxygen Species | dynamin 1-like | Mus musculus |
| 2 | BACKGROUND/AIMS: Inhibition of Drp-1-mediated mitochondrial fission limits reactive oxygen species (ROS) production and apoptosis in cardiomyocytes subjected to ischemia/reperfusion injury. | Reactive Oxygen Species | dynamin 1-like | Mus musculus |
| 3 | RESULTS: Inhibition of Drp1 and Dynamin 2 protected against mitochondrial fragmentation, maintained DeltaPsim, attenuated cellular ROS production and limited apoptosis. | Reactive Oxygen Species | dynamin 1-like | Mus musculus |
| 4 | CONCLUSIONS: Oxidative stress-induced apoptosis and ROS production are attenuated by not only Drp1 inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes. | Reactive Oxygen Species | dynamin 1-like | Mus musculus |