Pub. Date : 2017 Jan 4
PMID : 27797821
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using an adaptation of our in vitro primary epithelial cell culture system, we found that prostaglandin E2 (PGE2) signaling through one of its receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptionally similar to in vivo WAE cells. | Dinoprostone | prostaglandin E receptor 4 (subtype EP4) | Mus musculus |
| 2 | Using an adaptation of our in vitro primary epithelial cell culture system, we found that prostaglandin E2 (PGE2) signaling through one of its receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptionally similar to in vivo WAE cells. | Dinoprostone | prostaglandin E receptor 4 (subtype EP4) | Mus musculus |
| 3 | Creation of WAE cells via the PGE2-Ptger4 pathway was required in vivo, as mice with loss of Ptger4 in the intestinal epithelium did not produce WAE cells and exhibited impaired wound repair. | Dinoprostone | prostaglandin E receptor 4 (subtype EP4) | Mus musculus |