Title : Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.

Pub. Date : 2016 Nov 29

PMID : 27793025






1 Functional Relationships(s)
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1 Treatment with GLI1/2 inhibitors, including arsenic trioxide, significantly increased GLI3 binding to the KIT promoter, decreased KIT expression, and reduced viability in imatinib-sensitive and imatinib-resistant GIST cells. Arsenic Trioxide GLI family zinc finger 1 Homo sapiens