Title : Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

Pub. Date : 2016 Jul

PMID : 27773949






1 Functional Relationships(s)
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1 The key step in the synthesis is oxidative olefin cleavage of delta-tocotrienol to afford the chroman core of 1 with retention of chirality at the C-2 stereocenter. Alkenes complement C2 Homo sapiens