Title : Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress.

Pub. Date : 2017 Nov

PMID : 27771902






2 Functional Relationships(s)
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1 We found that RA treatment for 7 days reduced the cell number and proliferative capacity and induced the expression of adult catecholaminergic/neuronal markers such as tyrosine hydroxylase (TH), beta-III tubulin, and enolase-2. Tretinoin enolase 2 Homo sapiens
2 Importantly, Trolox co-treatment inhibited the appearance of morphological characteristics such as neurite extension and branching, and decreased the expression of TH, beta-III tubulin, and enolase-2 after a seven-day differentiation with RA, indicating that RS production is a necessary step in this process. Tretinoin enolase 2 Homo sapiens