Pub. Date : 2016 Oct 21
PMID : 27769261
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | GCR must be bound to molecular chaperones heat shock proteins (Hsp) 70 and Hsp90 to acquire a high-affinity steroid binding conformation, and traffic to the nucleus. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | CONCLUSIONS: Loss of Hsp90 from cytotoxic/pro-inflammatory CD28nullCD8+ T and NKT-like cells could contribute to steroid resistance in COPD. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |