Title : Valproic acid (VPA) promotes the epithelial mesenchymal transition of hepatocarcinoma cells via transcriptional and post-transcriptional up regulation of Snail.

Pub. Date : 2016 Dec

PMID : 27768928






2 Functional Relationships(s)
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1 The increased protein stabilization of Snail can be attributed to VPA induced phosphorylation of Akt and GSK-3beta. Valproic Acid glycogen synthase kinase 3 beta Homo sapiens
2 Collectively, our present study revealed that VPA can promote the EMT of HCC cells via up regulation of Snail through activation of NF-kappaB and Akt/GSK-3beta signals. Valproic Acid glycogen synthase kinase 3 beta Homo sapiens