Title : Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.

Pub. Date : 2017 Mar

PMID : 27763682






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1 CONCLUSION: Opicapone, as once-daily oral evening regimen and/or 1 h apart from levodopa therapy, increases the bioavailability of levodopa associated with its pronounced, long-lasting and sustained catechol-O-methyltransferase inhibition. Levodopa catechol-O-methyltransferase Homo sapiens