Pub. Date : 2017
PMID : 27758758
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 2 | Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 3 | Objectives: To compare the ability of rupatadine to inhibit PAF-induced MC degranulation with that of desloratadine and levocetirizine and to confirm the dual anti-H1 and anti-PAF activity of rupatadine. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 4 | Objectives: To compare the ability of rupatadine to inhibit PAF-induced MC degranulation with that of desloratadine and levocetirizine and to confirm the dual anti-H1 and anti-PAF activity of rupatadine. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 5 | RESULTS: CV6209 and rupatadine inhibited PAF-induced MC degranulation in both LAD2 and hLMCs. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 6 | In LAD2, rupatadine (5 and 10 microM) and levocetirizine (5 microM), but not desloratadine, inhibited PAF-induced b-hexosaminidase release. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 7 | Rupatadine (1-10 microM), levocetirizine (1-10 microM), and desloratadine (10 microM) inhibited PAF-induced histamine release. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 8 | CONCLUSIONS: This study shows that rupatadine and, to a lesser extent, levocetirizine, but not desloratadine, inhibit PAF-induced degranulation in both LAD2 and hLMCs. | rupatadine | PCNA clamp associated factor | Homo sapiens |
| 9 | These findings support the dual antihistamine and anti-PAF effect of rupatadine in allergic disorders. | rupatadine | PCNA clamp associated factor | Homo sapiens |