Title : Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).

Pub. Date : 2017

PMID : 27758758






9 Functional Relationships(s)
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1 Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. rupatadine PCNA clamp associated factor Homo sapiens
2 Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. rupatadine PCNA clamp associated factor Homo sapiens
3 Objectives: To compare the ability of rupatadine to inhibit PAF-induced MC degranulation with that of desloratadine and levocetirizine and to confirm the dual anti-H1 and anti-PAF activity of rupatadine. rupatadine PCNA clamp associated factor Homo sapiens
4 Objectives: To compare the ability of rupatadine to inhibit PAF-induced MC degranulation with that of desloratadine and levocetirizine and to confirm the dual anti-H1 and anti-PAF activity of rupatadine. rupatadine PCNA clamp associated factor Homo sapiens
5 RESULTS: CV6209 and rupatadine inhibited PAF-induced MC degranulation in both LAD2 and hLMCs. rupatadine PCNA clamp associated factor Homo sapiens
6 In LAD2, rupatadine (5 and 10 microM) and levocetirizine (5 microM), but not desloratadine, inhibited PAF-induced b-hexosaminidase release. rupatadine PCNA clamp associated factor Homo sapiens
7 Rupatadine (1-10 microM), levocetirizine (1-10 microM), and desloratadine (10 microM) inhibited PAF-induced histamine release. rupatadine PCNA clamp associated factor Homo sapiens
8 CONCLUSIONS: This study shows that rupatadine and, to a lesser extent, levocetirizine, but not desloratadine, inhibit PAF-induced degranulation in both LAD2 and hLMCs. rupatadine PCNA clamp associated factor Homo sapiens
9 These findings support the dual antihistamine and anti-PAF effect of rupatadine in allergic disorders. rupatadine PCNA clamp associated factor Homo sapiens