Pub. Date : 2016 Dec 2
PMID : 27756843
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Steady-state kinetic analyses and binding assays were consistent with Sirt1 S-nitrosation inhibiting binding of both the NAD+ and acetyl-lysine substrates. | N(alpha)-acetyllysine | sirtuin 1 | Homo sapiens |
| 2 | Molecular dynamics simulations suggested that Zn2+ loss due to Sirt1 S-nitrosation results in repositioning of the tetrathiolate subdomain away from the rest of the catalytic domain, thereby disrupting the NAD+ and acetyl-lysine-binding sites. | N(alpha)-acetyllysine | sirtuin 1 | Homo sapiens |