Title : Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.

Pub. Date : 2016 Dec 2

PMID : 27756840






1 Functional Relationships(s)
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1 We report here that movement of helical residues 120-122 and loop residues 123-129 of Eallo underlies the allosteric effects of FAs and allosteric COX-2 inhibitors, including naproxen and flurbiprofen. Flurbiprofen prostaglandin-endoperoxide synthase 2 Homo sapiens