Title : Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors.

Pub. Date : 2016 Dec 8

PMID : 27753480






1 Functional Relationships(s)
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1 These compounds were able to decrease efficiently Pgp mediated influx and efflux of rhodamine-123 (Rho) and to restore the cytotoxicity of vinorelbine 3 (VLN) and doxorubicin (Dox) on K562R (dox-resistant) cell lines. Rhodamine 123 ATP binding cassette subfamily B member 1 Homo sapiens