Title : Hydrogen sulfide suppresses angiotensin II-stimulated endothelin-1 generation and subsequent cytotoxicity-induced endoplasmic reticulum stress in endothelial cells via NF-κB.

Pub. Date : 2016 Nov

PMID : 27748925






4 Functional Relationships(s)
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Protein Name
Organism
1 The effects of AngII were abrogated by sodium hydrosulfide (NaHS, an H2S donor), BQ788 or pyrrolidinedithiocarbamic acid (PDTC, an inhibitor of NF-kappaB). sodium bisulfide angiotensinogen Homo sapiens
2 The effects of AngII were abrogated by sodium hydrosulfide (NaHS, an H2S donor), BQ788 or pyrrolidinedithiocarbamic acid (PDTC, an inhibitor of NF-kappaB). sodium bisulfide angiotensinogen Homo sapiens
3 Furthermore, pretreatment with NaHS or PDTC attenuated AngII-induced apoptosis and cleaved caspase-12 generation. sodium bisulfide angiotensinogen Homo sapiens
4 The pretreatment of HUVECs with BQ788 prior to AngII exposure mimicked the inhibitory effect of NaHS on the expression of p-p65 induced by AngII. sodium bisulfide angiotensinogen Homo sapiens