Pub. Date : 2016 Nov 11
PMID : 27743890
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3beta phosphorylation. | Simvastatin | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4. | Simvastatin | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4. | Simvastatin | glycogen synthase kinase 3 beta | Homo sapiens |