Title : Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation.

Pub. Date : 2016 Nov 11

PMID : 27743890






3 Functional Relationships(s)
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Protein Name
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1 Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3beta phosphorylation. Simvastatin glycogen synthase kinase 3 beta Homo sapiens
2 Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4. Simvastatin glycogen synthase kinase 3 beta Homo sapiens
3 Simvastatin also decreased phosphorylation of insulin receptor (IR), insulin receptor substrate 1 (IRS-1), AKT and glycogen synthase kinase 3beta (GSK-3beta), and downregulated GLUT4. Simvastatin glycogen synthase kinase 3 beta Homo sapiens