Title : Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells.

Pub. Date : 2016 Nov 15

PMID : 27732942






3 Functional Relationships(s)
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1 Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway. Tetracycline nuclear factor kappa B subunit 1 Homo sapiens
2 Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway. Tetracycline nuclear factor kappa B subunit 1 Homo sapiens
3 Constitutive or aberrant activation of NF-kappaB is encountered in many types of cancer, including CTCL.Recently, while analyzing gene-expression profiles of a variety of small molecule compounds that target NF-kappaB, we discovered the tetracycline family of antibiotics, including doxycycline, to be potent inhibitors of the NF-kappaB pathway. Tetracycline nuclear factor kappa B subunit 1 Homo sapiens