Title : In-vitro investigation regarding the effects of Gelucire® 44/14 and Labrasol® ALF on the secretory intestinal transport of P-gp substrates.

Pub. Date : 2016 Dec 30

PMID : 27720954






2 Functional Relationships(s)
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1 In this present study, the secretory transport of P-gp substrates, rhodamine 123 and digoxin, was evaluated using a Caco-2/HT29-MTX co-culture characterized by an efflux mechanism and a paracellular permeability closer to the human intestinal barrier compared to the Caco-2 monolayer gold standard. Rhodamines phosphoglycolate phosphatase Homo sapiens
2 Labrasol ALF and Gelucire 44/14 in saline buffer significantly decreased to 83% and 62%, the P-gp-mediated transport of rhodamine 123 across the co-culture, respectively. Rhodamines phosphoglycolate phosphatase Homo sapiens