Pub. Date : 2016 Nov
PMID : 27716962
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Continuously produced Ach suppressed IFNalpha-induced STAT1 phosphorylation, but increased the level of a protease, USP18 (both measured by Western blot), which interferes with IFNalpha signaling. | Acetaldehyde | interferon alpha 1 | Homo sapiens |
| 2 | RESULTS: Continuously produced Ach suppressed IFNalpha-induced STAT1 phosphorylation, but increased the level of a protease, USP18 (both measured by Western blot), which interferes with IFNalpha signaling. | Acetaldehyde | interferon alpha 1 | Homo sapiens |
| 3 | CONCLUSIONS: We conclude that Ach disrupts IFNalpha-induced STAT1 phosphorylation by the up-regulation of USP18 to block the innate immunity protection in HCV-infected liver cells, thereby contributing to HCV-alcohol pathogenesis. | Acetaldehyde | interferon alpha 1 | Homo sapiens |