Pub. Date : 2016 Sep 30
PMID : 27716272
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. | trichostatin A | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Furthermore, siRNA assays were performed to analyse the role of p21 and p53 on TSA-mediated anti-lymphangiogenic effects. | trichostatin A | H3 histone pseudogene 16 | Homo sapiens |
| 3 | Additionally, we observed that p21 protein accumulated in cellular nuclei after treatment with TSA. | trichostatin A | H3 histone pseudogene 16 | Homo sapiens |
| 4 | Interestingly, siRNA-mediated p21 depletion almost completely reversed the anti-proliferative effects of TSA in LEC. | trichostatin A | H3 histone pseudogene 16 | Homo sapiens |