Title : Essential Role of CFTR in PKA-Dependent Phosphorylation, Alkalinization, and Hyperpolarization During Human Sperm Capacitation.

Pub. Date : 2017 Jun

PMID : 27714810






1 Functional Relationships(s)
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1 It is well established that HCO3- is essential for capacitation because it activates the atypical soluble adenylate cyclase ADCY10 leading to cAMP production, and promotes alkalinization of cytoplasm, and membrane hyperpolarization. Bicarbonates adenylate cyclase 10 Homo sapiens