Title : Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB.

Pub. Date : 2016 Oct 6

PMID : 27711079






1 Functional Relationships(s)
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1 Ablation of Sirt1 shows remarkable protection against GalN/LPS-induced liver injury, which is a result of enhanced NF-kappaB response because knockdown of RelA/p65 negates the protective effect of Sirt1 knockout. Galactosamine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus