Title : ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation.

Pub. Date : 2016 Oct 6

PMID : 27708396






3 Functional Relationships(s)
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1 Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Here, we demonstrate that ERK/c-Jun signaling is involved in DNA demethylation of EBV immediate early (IE) gene Zta in response to 12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulation. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Thus, TPA activates ERK/c-Jun signaling, which subsequently facilitates Tet1 to bind to Zta promoter, leading to DNA demethylation, gene expression, and EBV reactivation. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens