Pub. Date : 2016 Oct 4
PMID : 27698449
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | By applying antioxidant Trolox, we also confirmed that ROS mediated p53 activation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | We found p53 could inhibit pro-survival genes B-cell lymphoma-2 (Bcl-2), myeloid leukemia-1 (Mcl-1) and S phase related cell cycle proteins cyclin-dependent kinase 2 (CDK2), Cyclin E to induce premature senescence, and the functional role of ROS in Cr(VI)-induced premature senescence is depend on p53. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | The results suggest that Cr(VI) has a role in premature senescence by promoting ROS-dependent p53 activation in L-02 hepatocytes. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |