Pub. Date : 2016 Dec 8
PMID : 27694321
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 2 | This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 3 | This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 4 | This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 5 | This additional effect of ticagrelor beyond P2Y12R antagonism was in part as a consequence of ticagrelor inhibiting the equilibrative nucleoside transporter 1 (ENT1) on platelets, leading to accumulation of extracellular adenosine and activation of Gs-coupled adenosine A2A receptors. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |
| 6 | In summary, our studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation. | Ticagrelor | solute carrier family 29 member 1 (Augustine blood group) | Homo sapiens |