Title : Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/β-catenin signaling pathways.

Pub. Date : 2016 Dec 28

PMID : 27693558






3 Functional Relationships(s)
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1 We show that TPA treatment activates MEK1, ERK1/2 and downstream effector AP-1 in wild-type (WT) epidermal cells and mice, but not in cells or mice where Lgr4 is depleted. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 3 Mus musculus
2 We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 3 Mus musculus
3 We provide evidences that blocking both MEK1/ERK1/2 and Wnt/beta-catenin pathways prevents TPA-induced increase in the expression of Ccnd1 (cyclin D1), a known Wnt/beta-catenin target gene, and that the activation of MEK1/ERK1/2 pathway lies upstream of Wnt/beta-catenin signal pathway. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 3 Mus musculus