Title : Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects.

Pub. Date : 2017 Oct

PMID : 27690733






6 Functional Relationships(s)
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1 Carbamazepine (CBZ) is an antiepileptic drug with narrow therapeutic window and administration in humans receiving long-term therapy with diosmin (DSN) may occur, which leads to CYP3A4-mediated drug interactions. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Carbamazepine (CBZ) is an antiepileptic drug with narrow therapeutic window and administration in humans receiving long-term therapy with diosmin (DSN) may occur, which leads to CYP3A4-mediated drug interactions. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
5 The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens
6 The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens