Pub. Date : 2017 Oct
PMID : 27690733
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Carbamazepine (CBZ) is an antiepileptic drug with narrow therapeutic window and administration in humans receiving long-term therapy with diosmin (DSN) may occur, which leads to CYP3A4-mediated drug interactions. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Carbamazepine (CBZ) is an antiepileptic drug with narrow therapeutic window and administration in humans receiving long-term therapy with diosmin (DSN) may occur, which leads to CYP3A4-mediated drug interactions. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |