Title : NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells.

Pub. Date : 2016 Oct 28

PMID : 27687548






3 Functional Relationships(s)
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Protein Name
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1 NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens