Pub. Date : 2016 Oct 28
PMID : 27687548
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells. | Meloxicam | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
2 | Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2. | Meloxicam | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
3 | CONCLUSION: Indomethacin, diclofenac, and meloxicam highly upregulated radiation-induced expression of ICAM-1 and COX-2 in HUVECs, which suggests that use of these NSAIDs may increase the effects of ionizing radiation and affect the risk of MI after radiation exposure to the heart. | Meloxicam | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |