Title : Effect of Polyaryl Hydrocarbons on Cytotoxicity in Monocytic Cells: Potential Role of Cytochromes P450 and Oxidative Stress Pathways.

Pub. Date : 2016

PMID : 27684561






2 Functional Relationships(s)
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1 RESULTS: Of the five PAHs tested, after chronic treatment only BaP (100 nM) showed a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 However, acute treatment with BaP showed only an increase in the mRNA expression of CYP1A1. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens