Pub. Date : 2017 Feb 1
PMID : 27676604
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of OCTs or MATEs in HEK293 cells resulted in an up to 63-fold increase in the uptake of ipratropium (Km of 0.32 mum to OCT2 and Vmax of 3.34 nmolxmg protein-1xmin-1 to MATE1). | Ipratropium | solute carrier family 22 member 2 | Homo sapiens |
| 2 | Genetic polymorphisms in OCT1 and OCT2 affected ipratropium uptake and clinically relevant concentration of ondansetron and pyrithiamine inhibited ipratropium uptake via MATEs by more than 90%. | Ipratropium | solute carrier family 22 member 2 | Homo sapiens |
| 3 | This study suggests that OCT1, OCT2 and MATEs may be strongly involved in the renal and extra-renal elimination of ipratropium and other quaternary amine alkaloids. | Ipratropium | solute carrier family 22 member 2 | Homo sapiens |