Pub. Date : 1989 Jun
PMID : 2766930
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simultaneous treatment of the rat hepatocyte-derived cell line LCS7 with cycloheximide and polycyclic aromatic compounds increased CYP1A1 (cytochrome P450c) gene transcription rate four- to sixfold and mRNA levels 20-fold relative to the levels in cells treated with inducers alone. | Cycloheximide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | Simultaneous treatment of the rat hepatocyte-derived cell line LCS7 with cycloheximide and polycyclic aromatic compounds increased CYP1A1 (cytochrome P450c) gene transcription rate four- to sixfold and mRNA levels 20-fold relative to the levels in cells treated with inducers alone. | Cycloheximide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | Thus, treatment with cycloheximide revealed two phases to the response of the CYP1A1 gene to inducer. | Cycloheximide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | All of these exhibited elevated levels of CYP1A1 mRNA following simultaneous treatment with inducer and cycloheximide; transcription rate was superinduced three- to fourfold in primary hepatocytes, and CYP1A1 mRNA levels were superinduced 20- to 25-fold in both kidney and lung explants. | Cycloheximide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |