Title : Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors.

Pub. Date : 2015 Jun

PMID : 27668268






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors. Lenalidomide negative elongation factor complex member C/D Homo sapiens
2 Lenalidomide increased the anti-tumor activities of XBP1-CTL memory subsets, which were associated with expression of Th1 transcriptional regulators (T-bet, Eomes) and Akt activation, thereby resulting in enhanced IFN-gamma production, granzyme B upregulation and specific CD28/CD38-positive and CTLA-4/PD-1-negative cell proliferation. Lenalidomide negative elongation factor complex member C/D Homo sapiens