Title : Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action.

Pub. Date : 2016 Nov

PMID : 27664318






1 Functional Relationships(s)
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1 MIBK induced hepatic effects are consistent with a phenobarbital-like MOA where the initiating events are activation of the CAR and PXR nuclear receptors and resultant hepatocellular proliferation leading to rodent liver tumors. Phenobarbital nuclear receptor subfamily 1, group I, member 2 Mus musculus