Title : Biophysical tools to assess the interaction of PF4 with polyanions.

Pub. Date : 2016 Oct 28

PMID : 27658429






5 Functional Relationships(s)
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1 Biophysical tools to assess the interaction of PF4 with polyanions. polyanions platelet factor 4 Homo sapiens
2 The antigen in heparin-induced thrombocytopenia (HIT) is expressed on platelet factor 4 (PF4) when PF4 complexes with polyanions. polyanions platelet factor 4 Homo sapiens
3 The antigen in heparin-induced thrombocytopenia (HIT) is expressed on platelet factor 4 (PF4) when PF4 complexes with polyanions. polyanions platelet factor 4 Homo sapiens
4 This allowed identification of those features that make PF4 immunogenic (e. g. a certain conformational change induced by the polyanion, a threshold energy of the complexes, the existence of multimeric complexes, a certain number of bonds formed by PF4 with the polyanion) and to characterize the morphology and thermal stability of complexes formed by the protein with polyanions. polyanions platelet factor 4 Homo sapiens
5 This allowed identification of those features that make PF4 immunogenic (e. g. a certain conformational change induced by the polyanion, a threshold energy of the complexes, the existence of multimeric complexes, a certain number of bonds formed by PF4 with the polyanion) and to characterize the morphology and thermal stability of complexes formed by the protein with polyanions. polyanions platelet factor 4 Homo sapiens