Title : Docosahexaenoic Acid Inhibits Tumor Promoter-Induced Urokinase-Type Plasminogen Activator Receptor by Suppressing PKCĪ“- and MAPKs-Mediated Pathways in ECV304 Human Endothelial Cells.

Pub. Date : 2016

PMID : 27654969






2 Functional Relationships(s)
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1 Specific inhibitors and mutagenesis studies showed that PKCdelta, JNK1/2, Erk1/2, NF-kappaB, and AP-1 were critical for TPA-induced uPAR expression. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
2 Application of DHA suppressed TPA-induced translocation of PKCdelta, activation of the JNK1/2 and Erk1/2 signaling pathways, and subsequent AP-1 and NF-kappaB transactivation. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens