Title : Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.

Pub. Date : 2017 Jul 20

PMID : 27649969






1 Functional Relationships(s)
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1 AIMS: In the heart, beta1-adrenergic signaling involves cyclic adenosine monophosphate (cAMP) acting via both protein kinase-A (PKA) and exchange protein directly activated by cAMP (Epac): a guanine nucleotide exchange factor for the small GTPase Rap1. Guanine Nucleotides Rap guanine nucleotide exchange factor 3 Homo sapiens