Title : Inhibition of the PI3K/AKT Pathway Sensitizes Oral Squamous Cell Carcinoma Cells to Anthracycline-Based Chemotherapy In Vitro.

Pub. Date : 2017 Sep

PMID : 27649518






3 Functional Relationships(s)
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Protein Name
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1 Dox and AD198 increased activation of AKT, ERK1/2, and p38 MAPK signaling pathways in tested OSCC cells by dose-dependent manner. Doxorubicin mitogen-activated protein kinase 3 Homo sapiens
2 Dox and AD198 increased activation of AKT, ERK1/2, and p38 MAPK signaling pathways in tested OSCC cells by dose-dependent manner. Doxorubicin mitogen-activated protein kinase 3 Homo sapiens
3 Inhibition of PI3K/AKT reduced Dox- and AD198-induced activation of ERK1/2 and further increased Dox- and AD198-induced phosphorylation of p38 MAPK in OSCC. Doxorubicin mitogen-activated protein kinase 3 Homo sapiens