Title : Role of exposure/recovery schedule in micronuclei induction by several promutagens in V79-derived cells expressing human CYP2E1 and SULT1A1.

Pub. Date : 2016 Sep 15

PMID : 27637483






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 1-Hydroxymethylpyrene (activated by SULT1A1) and 1-methylpyrene (activated sequentially by CYP2E1 and SULT1A1) produced the highest response with the 18h/6h treatment regimen. 1-methylpyrene sulfotransferase family 1A member 1 Homo sapiens
2 Moreover, mitotic arrest by 1-hydroxymethylpyrene was observed in V79-hCYP2E1-hSULT1A1 cells but not in V79 cells, and 1-methylpyrene arrested mitosis in V79-hCYP2E1-hSULT1A1 more strongly than in V79 cells. 1-methylpyrene sulfotransferase family 1A member 1 Homo sapiens